Other indications include skeletal muscle spasticity, catatonia, eclampsia, sleepwalking, night terrors, and chemotherapy-induced nausea and vomiting.Preoperative and procedural sedation : diazepam, lorazepam, midazolam.Seizures and status epilepticus : diazepam, lorazepam, midazolam, clonazepam.Alcohol withdrawal : chlordiazepoxide, diazepam, oxazepam.Insomnia : flurazepam, temazepam, triazolam, lormetazepam.Anxiety disorders : chlordiazepoxide, diazepam, clonazepam, lorazepam, oxazepam, alprazolam.Benzodiazepines decrease the duration of N3 phase in NREM sleep, thereby reducing the occurrence of sleepwalking and night terrorsīenzo increases the frequenzo of Cl-channel opening.Benzodiazepines are in direct GABA A receptor agonists that bind to GABA-A receptors → ↑ affinity of GABA to bind to GABA A receptors → ↑ GABA action → ↑ opening frequency of chloride channels → hyperpolarization of the postsynaptic neuronal membrane → ↓ neuronal excitability.Long-acting : ( half-life > 40 hours) : diazepam, chlordiazepoxide, clonazepam, tetrazepam, flurazepam.Intermediate-acting : ( half-life 12–40 hours) : lorazepam, temazepam, oxazepam, lormetazepam, alprazolam.Short-acting : ( half-life 1–12 hours) : midazolam, triazolam.Sleep disturbances: abnormal dreams, nightmares, sleep terrors.Antagonism of orexin ( hypocretin) receptors → ↓ wakefulness.Activation of MT1 and MT2 receptors in suprachiasmatic nuclei of the hypothalamus → ↓ sleep-onset latency.Generalized-onset and focal-onset seizures.Intermediate-acting: amobarbital, butalbital Short-term treatment for insomnia or anxiety. Short-acting: pentobarbital, secobarbital GABA A receptor agonism → ↓ neuronal excitability in the brain → ↓ ICP and sedative, hypnotic, and antiepileptic effects.Ultra-short acting: thiopental, methohexital Long-acting: diazepam, chlordiazepoxide, clonazepam, tetrazepam, flurazepam Intermediate-acting: lorazepam, temazepam, oxazepam, lormetazepam, alprazolam Indirect GABA A receptor agonism → ↓ neuronal excitability.Chemotherapy-induced nausea and vomiting.
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Jewish guy sees a financial opportunity in Herc. So enjoy listening to Arnie struggle with the script. And the original audio is still available. You can still find it on the internet if you’re interested. His delivery was deemed unusable for the final cut by the studio and was overdubbed at the last hour. His English was quite broken, still learning and picking up the language as he trained with other muscle men. Secondly, this was at a time when Arnold was new to America. They had deemed his birth name, too long. Firstly they changed Arnie’s name for the credits. Arnold describes it in his autobiography as his big break. What were they thinking when they made this film? For those of you who don’t know, this film is Schwarzenegger’s first step into the movie industry. His name alone, makes a movie poster look ‘badass’ This is a look at the best and the worst of the Governator himself, Arnold Schwarzenegger. Some of which will be hard to match for years to come. But his career has delivered some of the greatest action movies of all time. He has, however, fallen from his previous relevancy, with a few career missteps since his departure from politics. He his a true phenomenon and the ultimate proof that the ‘American dream’ is possible. Everyone seems to be born with their own impression of the man. People of all ages are aware of him or familiar with his work. Incredibly recognizable in both stature and voice. Love him or hate him, Arnie is a cultural icon. |